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Savor award-winning cuisine and an extensive bourbon collection at the on-site restaurant, known for its vibrant decor and locally sourced menu.
Enjoy thoughtful room details like black-light bathroom settings that create a glowing blue ambiance and designer toiletries for a spa-like feel.
Relax and recharge with on-site spa treatments, a sauna, and a steam room, or maintain your routine in the well-appointed 24-hour fitness center.
Explore downtown Louisville from West Main Street, situated steps from the Louisville Slugger Museum and just a 10-minute walk to Whiskey Row.
Elevate your visit in the exclusive rooftop suite, which offers a full kitchen and a private garden terrace overlooking the Louisville streetscape.
Discover the hotel's signature life-sized sculptures that move throughout the property daily, adding a whimsical and interactive touch to your stay.
The 5-star 21c Museum Hotel Louisville is set within five renovated 19th-century bourbon and tobacco warehouses, functioning as both a hotel and a contemporary art museum. It features the award-winning Proof on Main restaurant, serving American cuisine with a Southern twist, and displays a prominent golden David sculpture visible from a distance. Guests can experience the unique Asleep in the Cyclone room art installation or encounter the iconic red penguin art installations throughout the property. The hotel has a review score of 9.2 based on over 5,000 reviews, with atmosphere, restaurant, and overall experience highlighted positively by guests.
This hotel is a vibrant urban hub catering to luxury travelers, sightseers, and groups of friends seeking a unique and immersive experience. Its excellent location in downtown Louisville provides easy walking access to major attractions like the Louisville Slugger Museum, Muhammad Ali Center, and numerous Bourbon distilleries along Whiskey Row. The property distinguishes itself with a unique blend of facilities, notably functioning as an art museum with thought-provoking installations and rotating exhibits. Guests consistently praise the welcoming and professional staff and service, and the on-site restaurant, Proof on Main, is frequently highlighted for its exceptional food and cocktails. For a truly distinctive stay, consider booking the "Asleep in the Cyclone" room, an immersive art installation that doubles as a guest room.
Distance from 21c Museum Hotel Louisville
Muhammad Ali Center:0.2 km
Louisville Slugger Museum & Factory:0.2 km
Louisville:0.4 km
Belle of Louisville:0.6 km
KFC Yum! Center:0.7 km
Transit Authority of River City:1.3 km
Louisville Slugger Field:1.5 km
Lynn Family Stadium:2.6 km
J B Speed Art Museum:4.4 km
L&N Federal Credit Union Stadium:5.7 km
Louisville Zoo:7.6 km
Louisville Muhammad Ali International Airport:9.6 km
No, 21c Museum Hotel Louisville doesn’t offer pool areas.
Yes, 21c Museum Hotel Louisville has a pet policy that may vary based on the room type or availability. Please check with the hotel directly to learn about their pet policy.
Yes, 21c Museum Hotel Louisville provides Accessible parking for guests.
Check-in at 21c Museum Hotel Louisville is available from: . Check-out time is by .
21c Museum Hotel Louisville is located in 700 W Main St, 40202, Louisville, USA.
The prices and availability we receive from booking sites change constantly. This means you may not always find the exact same offer you saw on trivago when you land on the booking site.